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K145 hydrochloride
CAS No. 1449240-68-9
K145 hydrochloride ( —— )
产品货号. M29603 CAS No. 1449240-68-9
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 μM and Ki of 6.4 μM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥405 | 有现货 |
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| 10MG | ￥551 | 有现货 |
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| 25MG | ￥786 | 有现货 |
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| 50MG | ￥1094 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称K145 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 μM and Ki of 6.4 μM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
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产品描述K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 μM and Ki of 6.4 μM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.(In Vitro):K145 hydrochloride inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30 μM. The Lineweaver-Burk analysis revealed a Ki of 6.4±0.7 μM for SphK2 and indicated that K145 hydrochloride is a substrate competitive inhibitor (with sphingosine). K145 hydrochloride accumulates in U937 cells, suppresses the S1P level, and inhibits SphK2. K145 hydrochloride also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells, and that these effects may be through the inhibition of downstream ERK and Akt signaling pathways.(In Vivo):In BALB/c-nu mice injected with U937 cells, K145 hydrochloride (50 mg/kg; oral gavage; for 15 days) treatment significantly inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed.
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis
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研究领域——
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适应症——
化学信息
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CAS Number1449240-68-9
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分子量384.9
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分子式C18H25ClN2O3S
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.CCCCOc1ccc(CC\C=C2/SC(=O)N(CCN)C2=O)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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